To add a bit to scuzzy's advice, I would recommend you dump eBlaster and ZoneAlarm. I am using Win7, I only run MSSE in realtime. I use the Windows firewall. I run Antimalwarebytes every couple of weeks, AdwCleaner only if I have a problem, ditto with RogueKiller.
I really think for the typical home user, the whole malware thing is way overblown.
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